Assay Detail
Binding
CHEMBL804188
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The binding affinity at the 5-HT reuptake sites determined using competition binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.62 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111184 | — | — | 1 | 5.78 |
| CHEMBL324270 | — | — | 1 | 5.54 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 5.54 |
| CHEMBL113238 | — | — | 1 | - |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111184 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL324270 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL6437 | MIANSERIN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL113238 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL654 | MIRTAZAPINE | IC50 | > | 100.0 | nM | - |