Assay Detail
Binding
CHEMBL804530
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Inhibition of binding to sodium channel of rat cerebral cortex
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2095171) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.41 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288505 | — | — | 1 | 4.41 |
| CHEMBL16 | PHENYTOIN | 4.0 | 1 | 4.40 |
| CHEMBL70727 | — | — | 1 | - |
| CHEMBL288861 | — | — | 1 | - |
| CHEMBL39010 | — | — | 1 | - |
| CHEMBL41666 | — | — | 1 | - |
| CHEMBL38675 | — | — | 1 | - |
| CHEMBL39126 | — | — | 1 | - |
| CHEMBL695 | TRIMETHADIONE | 4.0 | 1 | - |
| CHEMBL39810 | — | — | 1 | - |
| CHEMBL1169567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288505 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL16 | PHENYTOIN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL70727 | — | IC50 | = | 380000.0 | nM | - |
| CHEMBL288861 | — | IC50 | = | 162000.0 | nM | - |
| CHEMBL39010 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL41666 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL38675 | — | IC50 | = | 700000.0 | nM | - |
| CHEMBL39126 | — | IC50 | = | 427000.0 | nM | - |
| CHEMBL695 | TRIMETHADIONE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL39810 | — | IC50 | = | 285000.0 | nM | - |
| CHEMBL1169567 | — | IC50 | = | 160000.0 | nM | - |