Assay Detail
Binding
CHEMBL804589
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In vitro binding affinity on cloned Serotonin transporter
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.18 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432394 | — | — | 1 | 9.57 |
| CHEMBL104673 | — | — | 1 | 9.48 |
| CHEMBL106939 | DASB | 1.0 | 1 | 8.96 |
| CHEMBL107077 | — | — | 1 | 8.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432394 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL104673 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL106939 | DASB | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL107077 | — | Ki | = | 1.89 | nM | 8.72 |