Assay Detail
Binding
CHEMBL804590
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards human serotonin transporter
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 8.23 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263424 | — | — | 1 | 9.22 |
| CHEMBL318235 | — | — | 1 | 8.92 |
| CHEMBL98541 | — | — | 1 | 8.89 |
| CHEMBL101411 | — | — | 1 | 8.89 |
| CHEMBL99868 | — | — | 1 | 8.80 |
| CHEMBL101596 | — | — | 1 | 8.72 |
| CHEMBL91157 | — | — | 1 | 8.64 |
| CHEMBL95218 | — | — | 1 | 8.60 |
| CHEMBL98646 | — | — | 1 | 8.57 |
| CHEMBL319119 | — | — | 1 | 8.49 |
| CHEMBL419316 | — | — | 1 | 8.35 |
| CHEMBL328195 | — | — | 1 | 8.32 |
| CHEMBL328631 | — | — | 1 | 8.27 |
| CHEMBL419894 | — | — | 1 | 8.25 |
| CHEMBL419336 | — | — | 1 | 8.15 |
| CHEMBL329065 | — | — | 1 | 8.12 |
| CHEMBL328114 | — | — | 1 | 8.08 |
| CHEMBL319573 | — | — | 1 | 7.89 |
| CHEMBL99916 | — | — | 1 | 7.68 |
| CHEMBL319530 | — | — | 1 | 7.66 |
| CHEMBL420830 | — | — | 1 | 7.46 |
| CHEMBL101361 | — | — | 1 | 7.29 |
| CHEMBL98889 | — | — | 1 | 7.20 |
| CHEMBL100879 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263424 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL318235 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL98541 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL101411 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL99868 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL101596 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL91157 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL95218 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL98646 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL319119 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL419316 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL328195 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL328631 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL419894 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL419336 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL329065 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL328114 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL319573 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL99916 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL319530 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL420830 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL101361 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL98889 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL100879 | — | Ki | = | 74.0 | nM | 7.13 |