Assay Detail
Binding
CHEMBL804805
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Compound is evaluated for binding to Serotonin transporter using [3H]citalopram as radioligand in rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.87 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12227 | — | — | 1 | 6.43 |
| CHEMBL440272 | — | — | 1 | 5.92 |
| CHEMBL417249 | — | — | 1 | 5.84 |
| CHEMBL3084927 | — | — | 1 | 5.83 |
| CHEMBL11493 | — | — | 1 | 5.76 |
| CHEMBL11776 | — | — | 1 | 5.68 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12227 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL440272 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL417249 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL3084927 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL11493 | — | Ki | = | 1730.0 | nM | 5.76 |
| CHEMBL11776 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | = | 2440.0 | nM | 5.61 |