Assay Detail
Binding
CHEMBL804882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity measured on sigma opioid receptor using [3H]DTG as radioligand
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.12 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.25 |
| CHEMBL174083 | — | — | 1 | 8.01 |
| CHEMBL172161 | — | — | 1 | 7.48 |
| CHEMBL173190 | — | — | 1 | 7.28 |
| CHEMBL175300 | — | — | 1 | 7.28 |
| CHEMBL366459 | — | — | 1 | 7.27 |
| CHEMBL174300 | — | — | 1 | 7.26 |
| CHEMBL148055 | — | — | 1 | 7.26 |
| CHEMBL26929 | — | — | 1 | 7.22 |
| CHEMBL424125 | — | — | 1 | 7.19 |
| CHEMBL444590 | — | — | 1 | 7.17 |
| CHEMBL367723 | — | — | 1 | 7.06 |
| CHEMBL172363 | — | — | 1 | 7.03 |
| CHEMBL140406 | — | — | 1 | 7.00 |
| CHEMBL171181 | — | — | 1 | 6.90 |
| CHEMBL172556 | — | — | 1 | 6.86 |
| CHEMBL108241 | — | — | 1 | 6.82 |
| CHEMBL143110 | — | — | 1 | 6.76 |
| CHEMBL322275 | — | — | 1 | 6.70 |
| CHEMBL367435 | — | — | 1 | 6.64 |
| CHEMBL277302 | — | — | 1 | 6.61 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.58 |
| CHEMBL433972 | — | — | 1 | - |
| CHEMBL425134 | — | — | 1 | - |
| CHEMBL176819 | — | — | 1 | - |
| CHEMBL174703 | — | — | 1 | - |
| CHEMBL174554 | — | — | 1 | - |
| CHEMBL172601 | — | — | 1 | - |
| CHEMBL171974 | — | — | 1 | - |
| CHEMBL28209 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 5.64 | nM | 8.25 |
| CHEMBL174083 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL172161 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL173190 | — | IC50 | = | 52.2 | nM | 7.28 |
| CHEMBL175300 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL366459 | — | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL174300 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL148055 | — | IC50 | = | 54.4 | nM | 7.26 |
| CHEMBL26929 | — | IC50 | = | 59.9 | nM | 7.22 |
| CHEMBL424125 | — | IC50 | = | 64.1 | nM | 7.19 |
| CHEMBL444590 | — | IC50 | = | 67.5 | nM | 7.17 |
| CHEMBL367723 | — | IC50 | = | 87.5 | nM | 7.06 |
| CHEMBL172363 | — | IC50 | = | 92.8 | nM | 7.03 |
| CHEMBL140406 | — | IC50 | = | 99.1 | nM | 7.00 |
| CHEMBL171181 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL172556 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL108241 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL143110 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL322275 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL367435 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL277302 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL433972 | — | IC50 | - | — | - | |
| CHEMBL425134 | — | IC50 | - | — | - | |
| CHEMBL176819 | — | IC50 | - | — | - | |
| CHEMBL174703 | — | IC50 | - | — | - | |
| CHEMBL174554 | — | IC50 | - | — | - | |
| CHEMBL172601 | — | IC50 | - | — | - | |
| CHEMBL171974 | — | IC50 | - | — | - | |
| CHEMBL28209 | — | IC50 | - | — | - | |
| CHEMBL368477 | — | IC50 | - | — | - |