Assay Detail
Binding
CHEMBL804967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DTG binding to Sigma opioid receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.92 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19841 | — | — | 1 | 8.41 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.30 |
| CHEMBL281619 | — | — | 1 | 8.22 |
| CHEMBL53253 | — | — | 1 | 8.21 |
| CHEMBL19541 | — | — | 1 | 8.20 |
| CHEMBL296601 | — | — | 1 | 8.10 |
| CHEMBL19802 | — | — | 1 | 8.06 |
| CHEMBL298758 | — | — | 1 | 7.92 |
| CHEMBL19082 | — | — | 1 | 7.75 |
| CHEMBL25858 | — | — | 1 | 7.70 |
| CHEMBL20337 | — | — | 1 | 7.66 |
| CHEMBL20626 | — | — | 1 | 7.66 |
| CHEMBL55317 | — | — | 1 | 7.56 |
| CHEMBL55318 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19841 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL281619 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL53253 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL19541 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL296601 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL19802 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL298758 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19082 | — | Ki | = | 17.6 | nM | 7.75 |
| CHEMBL25858 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL20337 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL20626 | — | Ki | = | 21.8 | nM | 7.66 |
| CHEMBL55317 | — | Ki | = | 27.4 | nM | 7.56 |
| CHEMBL55318 | — | Ki | = | 83.2 | nM | 7.08 |