Assay Detail
Binding
CHEMBL804974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-citalopram from serotonin transporter of rat brain membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.20 | 6.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.53 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 5.49 |
| CHEMBL2112513 | — | — | 1 | 5.43 |
| CHEMBL2112516 | — | — | 1 | 5.35 |
| CHEMBL2112511 | — | — | 1 | 5.23 |
| CHEMBL2112514 | — | — | 1 | 5.10 |
| CHEMBL2112512 | — | — | 1 | 5.10 |
| CHEMBL113144 | — | — | 1 | 5.08 |
| CHEMBL113195 | — | — | 1 | 4.93 |
| CHEMBL2112515 | — | — | 1 | 4.86 |
| CHEMBL2112509 | — | — | 1 | 4.85 |
| CHEMBL2112510 | — | — | 1 | 4.83 |
| CHEMBL2112508 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL2112513 | — | Ki | = | 3730.0 | nM | 5.43 |
| CHEMBL2112516 | — | Ki | = | 4440.0 | nM | 5.35 |
| CHEMBL2112511 | — | Ki | = | 5850.0 | nM | 5.23 |
| CHEMBL2112514 | — | Ki | = | 7960.0 | nM | 5.10 |
| CHEMBL2112512 | — | Ki | = | 7960.0 | nM | 5.10 |
| CHEMBL113144 | — | Ki | = | 8290.0 | nM | 5.08 |
| CHEMBL113195 | — | Ki | = | 11700.0 | nM | 4.93 |
| CHEMBL2112515 | — | Ki | = | 13800.0 | nM | 4.86 |
| CHEMBL2112509 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL2112510 | — | Ki | = | 14800.0 | nM | 4.83 |
| CHEMBL2112508 | — | Ki | = | 16500.0 | nM | 4.78 |