Assay Detail
Binding
CHEMBL804977
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Displacement of [3H]citalopram from rat cortical serotonin transporter (SERT)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.67 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23034 | — | — | 1 | 10.89 |
| CHEMBL423269 | — | — | 1 | 10.52 |
| CHEMBL41140 | 6-NITROQUIPAZINE | — | 1 | 9.77 |
| CHEMBL166280 | — | — | 1 | 9.49 |
| CHEMBL167825 | — | — | 1 | 9.43 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 9.28 |
| CHEMBL167358 | — | — | 1 | 8.78 |
| CHEMBL167475 | — | — | 1 | 8.76 |
| CHEMBL166870 | — | — | 1 | 8.74 |
| CHEMBL166948 | — | — | 1 | 8.28 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 7.66 |
| CHEMBL167487 | — | — | 1 | 7.22 |
| CHEMBL353780 | — | — | 1 | 7.21 |
| CHEMBL436441 | — | — | 1 | 7.17 |
| CHEMBL422203 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23034 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL423269 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL41140 | 6-NITROQUIPAZINE | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL166280 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL167825 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL490 | PAROXETINE | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL167358 | — | Ki | = | 1.67 | nM | 8.78 |
| CHEMBL167475 | — | Ki | = | 1.73 | nM | 8.76 |
| CHEMBL166870 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL166948 | — | Ki | = | 5.23 | nM | 8.28 |
| CHEMBL41 | FLUOXETINE | Ki | = | 22.13 | nM | 7.66 |
| CHEMBL167487 | — | Ki | = | 60.03 | nM | 7.22 |
| CHEMBL353780 | — | Ki | = | 61.12 | nM | 7.21 |
| CHEMBL436441 | — | Ki | = | 67.24 | nM | 7.17 |
| CHEMBL422203 | — | Ki | = | 126.86 | nM | 6.90 |