Assay Detail
Binding
CHEMBL805114
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Inhibitory activity against T cell protein tyrosine phosphatase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | T-cell |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.19 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116605 | — | — | 1 | 7.19 |
| CHEMBL341103 | — | — | 1 | - |
| CHEMBL126613 | — | — | 1 | - |
| CHEMBL106109 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116605 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL341103 | — | Ki | = | 182000.0 | nM | - |
| CHEMBL126613 | — | Ki | = | 141000.0 | nM | - |
| CHEMBL106109 | — | Ki | > | 200000.0 | nM | - |