Assay Detail
Functional
CHEMBL805120
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Cytotoxicity against human Jurkat T cells.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.80 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152674 | — | — | 1 | 6.24 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.66 |
| CHEMBL154880 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152674 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL852 | MELPHALAN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL154880 | — | IC50 | = | 3090.0 | nM | 5.51 |