Assay Detail
Binding
CHEMBL805176
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Binding affinity for serotonin transporter is assessed from the ability to displace [3H]citalopram from rat brain.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.38 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2079577 | — | — | 1 | 7.18 |
| CHEMBL2112763 | — | — | 1 | 7.16 |
| CHEMBL2112762 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2079577 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL2112763 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2112762 | — | Ki | = | 16000.0 | nM | 4.80 |