Assay Detail
Binding
CHEMBL805178
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In vitro binding affinity in LLC-PK1 cells by SERT binding assay by using [125I]IDAM as a radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LLC-PK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 9.34 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23034 | — | — | 1 | 10.89 |
| CHEMBL142158 | — | — | 1 | 10.30 |
| CHEMBL114275 | — | — | 1 | 10.01 |
| CHEMBL107077 | — | — | 1 | 8.96 |
| CHEMBL106939 | DASB | 1.0 | 1 | 8.96 |
| CHEMBL143707 | — | — | 1 | 8.96 |
| CHEMBL22183 | — | — | 1 | 8.96 |
| CHEMBL356755 | — | — | 1 | 8.62 |
| CHEMBL142517 | — | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23034 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL142158 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL114275 | — | Ki | = | 0.097 | nM | 10.01 |
| CHEMBL107077 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL106939 | DASB | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL143707 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL22183 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL356755 | — | Ki | = | 2.39 | nM | 8.62 |
| CHEMBL142517 | — | Ki | = | 4.16 | nM | 8.38 |