Assay Detail
Binding
CHEMBL805319
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Affinity at rat serotonin transporter using [125I]RTI-55 displacement.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.41 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416409 | — | — | 1 | 7.06 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 6.90 |
| CHEMBL289013 | — | — | 1 | 6.79 |
| CHEMBL34032 | — | — | 1 | 6.77 |
| CHEMBL409161 | — | — | 1 | 6.70 |
| CHEMBL284096 | — | — | 1 | 6.69 |
| CHEMBL34591 | — | — | 1 | 6.62 |
| CHEMBL285673 | — | — | 1 | 6.62 |
| CHEMBL36419 | — | — | 1 | 6.61 |
| CHEMBL34372 | — | — | 1 | 6.61 |
| CHEMBL35045 | — | — | 1 | 6.58 |
| CHEMBL35411 | — | — | 1 | 6.43 |
| CHEMBL290799 | — | — | 1 | 6.41 |
| CHEMBL35122 | — | — | 1 | 6.36 |
| CHEMBL36074 | — | — | 1 | 6.34 |
| CHEMBL33902 | — | — | 1 | 6.28 |
| CHEMBL36141 | — | — | 1 | 6.22 |
| CHEMBL20648 | — | — | 1 | 6.04 |
| CHEMBL33903 | — | — | 1 | 6.00 |
| CHEMBL34697 | — | — | 1 | 5.67 |
| CHEMBL35239 | — | — | 1 | 5.65 |
| CHEMBL35005 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416409 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL281594 | VANOXERINE | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL289013 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL34032 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL409161 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL284096 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL34591 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL285673 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL36419 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL34372 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL35045 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL35411 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL290799 | — | Ki | = | 387.0 | nM | 6.41 |
| CHEMBL35122 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL36074 | — | Ki | = | 457.0 | nM | 6.34 |
| CHEMBL33902 | — | Ki | = | 531.0 | nM | 6.28 |
| CHEMBL36141 | — | Ki | = | 606.0 | nM | 6.22 |
| CHEMBL20648 | — | Ki | = | 902.0 | nM | 6.04 |
| CHEMBL33903 | — | Ki | = | 988.0 | nM | 6.00 |
| CHEMBL34697 | — | Ki | = | 2150.0 | nM | 5.67 |
| CHEMBL35239 | — | Ki | = | 2230.0 | nM | 5.65 |
| CHEMBL35005 | — | Ki | = | 2270.0 | nM | 5.64 |