Assay Detail
Binding
CHEMBL805322
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Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats
80
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 80 | 8.05 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152254 | — | — | 3 | 9.40 |
| CHEMBL149971 | — | — | 3 | 9.22 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 9.15 |
| CHEMBL357051 | — | — | 1 | 9.05 |
| CHEMBL150442 | — | — | 1 | 9.05 |
| CHEMBL153093 | — | — | 3 | 9.00 |
| CHEMBL152935 | — | — | 3 | 9.00 |
| CHEMBL348704 | — | — | 3 | 8.85 |
| CHEMBL356400 | — | — | 3 | 8.82 |
| CHEMBL358168 | — | — | 1 | 8.72 |
| CHEMBL149697 | — | — | 1 | 8.70 |
| CHEMBL357565 | — | — | 3 | 8.70 |
| CHEMBL447188 | — | — | 1 | 8.64 |
| CHEMBL356849 | — | — | 1 | 8.59 |
| CHEMBL152141 | — | — | 3 | 8.55 |
| CHEMBL149970 | — | — | 1 | 8.43 |
| CHEMBL436069 | — | — | 1 | 8.41 |
| CHEMBL149641 | — | — | 3 | 8.38 |
| CHEMBL151140 | — | — | 1 | 8.38 |
| CHEMBL345277 | — | — | 3 | 8.37 |
| CHEMBL153504 | — | — | 1 | 8.28 |
| CHEMBL356403 | — | — | 1 | 8.24 |
| CHEMBL153185 | — | — | 1 | 8.12 |
| CHEMBL356482 | — | — | 1 | 8.09 |
| CHEMBL150932 | — | — | 3 | 8.08 |
| CHEMBL153127 | — | — | 1 | 8.05 |
| CHEMBL152930 | — | — | 1 | 8.00 |
| CHEMBL151010 | — | — | 1 | 8.00 |
| CHEMBL153533 | — | — | 1 | 7.91 |
| CHEMBL153735 | — | — | 1 | 7.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152254 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL149971 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL490 | PAROXETINE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL357051 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL150442 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL153093 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL152935 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL152254 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL153093 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL153093 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL348704 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL356400 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL358168 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL152935 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL149697 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL357565 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL447188 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL149971 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL356400 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL356849 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL152141 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL356400 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL348704 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL149970 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL436069 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL151140 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL149641 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL345277 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL153504 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL357565 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL356403 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL149641 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL348704 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL152935 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL153185 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL356482 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL150932 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL153127 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL345277 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL152930 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL151010 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL152141 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL153533 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL153735 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL359345 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL346882 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL149971 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL153532 | — | Ki | = | 15.6 | nM | 7.81 |
| CHEMBL153676 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL152141 | — | Ki | = | 16.1 | nM | 7.79 |