Assay Detail
Binding
CHEMBL805326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]paroxetine from serotonin transporter (SERT)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.38 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419744 | — | — | 1 | 8.14 |
| CHEMBL326243 | — | — | 1 | 7.72 |
| CHEMBL113479 | — | — | 1 | 7.68 |
| CHEMBL109386 | — | — | 1 | 6.90 |
| CHEMBL113480 | — | — | 1 | 6.56 |
| CHEMBL112817 | — | — | 1 | 6.51 |
| CHEMBL607 | MEPERIDINE | 4.0 | 1 | 6.38 |
| CHEMBL110967 | — | — | 1 | 6.37 |
| CHEMBL113336 | — | — | 1 | 6.09 |
| CHEMBL324465 | — | — | 1 | 5.99 |
| CHEMBL323600 | — | — | 1 | 5.79 |
| CHEMBL324886 | — | — | 1 | 5.29 |
| CHEMBL324885 | — | — | 1 | 5.00 |
| CHEMBL111498 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419744 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL326243 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL113479 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL109386 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL113480 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL112817 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL607 | MEPERIDINE | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL110967 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL113336 | — | Ki | = | 805.0 | nM | 6.09 |
| CHEMBL324465 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL323600 | — | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL324886 | — | Ki | = | 5110.0 | nM | 5.29 |
| CHEMBL324885 | — | Ki | = | 10100.0 | nM | 5.00 |
| CHEMBL111498 | — | Ki | = | 13700.0 | nM | 4.86 |