Assay Detail
Binding
CHEMBL805328
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Binding affinity at serotonin transporter from rat caudate-putamen tissue by [3H]WIN-35428 displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of dopamine transporter selective 3-[2-(diarylmethoxyethylidene)]-8-alkylaryl-8-azabicyclo[3.2.1]octanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.90 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084919 | — | — | 1 | 6.76 |
| CHEMBL443291 | — | — | 1 | 6.75 |
| CHEMBL156286 | — | — | 1 | 6.43 |
| CHEMBL348907 | — | — | 1 | 6.25 |
| CHEMBL348583 | — | — | 1 | 6.19 |
| CHEMBL3084920 | — | — | 1 | 6.12 |
| CHEMBL160246 | — | — | 1 | 6.09 |
| CHEMBL157259 | — | — | 1 | 6.08 |
| CHEMBL157045 | — | — | 1 | 5.94 |
| CHEMBL160857 | — | — | 1 | 5.87 |
| CHEMBL157260 | — | — | 1 | 5.84 |
| CHEMBL346995 | — | — | 1 | 5.71 |
| CHEMBL157183 | — | — | 1 | 5.65 |
| CHEMBL126235 | — | — | 1 | 5.61 |
| CHEMBL160391 | — | — | 1 | 5.46 |
| CHEMBL76603 | — | — | 1 | 5.32 |
| CHEMBL349548 | — | — | 1 | 5.27 |
| CHEMBL3084922 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084919 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL443291 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL156286 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL348907 | — | Ki | = | 562.0 | nM | 6.25 |
| CHEMBL348583 | — | Ki | = | 651.0 | nM | 6.19 |
| CHEMBL3084920 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL160246 | — | Ki | = | 809.0 | nM | 6.09 |
| CHEMBL157259 | — | Ki | = | 822.0 | nM | 6.08 |
| CHEMBL157045 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL160857 | — | Ki | = | 1340.0 | nM | 5.87 |
| CHEMBL157260 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL346995 | — | Ki | = | 1940.0 | nM | 5.71 |
| CHEMBL157183 | — | Ki | = | 2220.0 | nM | 5.65 |
| CHEMBL126235 | — | Ki | = | 2470.0 | nM | 5.61 |
| CHEMBL160391 | — | Ki | = | 3430.0 | nM | 5.46 |
| CHEMBL76603 | — | Ki | = | 4780.0 | nM | 5.32 |
| CHEMBL349548 | — | Ki | = | 5420.0 | nM | 5.27 |
| CHEMBL3084922 | — | Ki | = | 14100.0 | nM | 4.85 |