Assay Detail
Binding
CHEMBL805329
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Binding affinity at Serotonin transporter using [3H]citalopram as radioligand from rat brain
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.50 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 6.98 |
| CHEMBL316244 | — | — | 1 | 5.91 |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | 5.77 |
| CHEMBL313179 | — | — | 1 | 5.67 |
| CHEMBL86830 | — | — | 1 | 5.37 |
| CHEMBL84971 | — | — | 1 | 5.30 |
| CHEMBL433340 | — | — | 1 | 4.88 |
| CHEMBL314433 | — | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL316244 | — | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL275707 | RIMCAZOLE | Ki | = | 1710.0 | nM | 5.77 |
| CHEMBL313179 | — | Ki | = | 2130.0 | nM | 5.67 |
| CHEMBL86830 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL84971 | — | Ki | = | 5010.0 | nM | 5.30 |
| CHEMBL433340 | — | Ki | = | 13100.0 | nM | 4.88 |
| CHEMBL314433 | — | Ki | = | 70900.0 | nM | 4.15 |