Assay Detail
Binding
CHEMBL805330
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Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.73 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.89 |
| CHEMBL70690 | — | — | 1 | 5.29 |
| CHEMBL70336 | — | — | 1 | 5.02 |
| CHEMBL72703 | — | — | 1 | - |
| CHEMBL421679 | — | — | 1 | - |
| CHEMBL72319 | — | — | 1 | - |
| CHEMBL70265 | — | — | 1 | - |
| CHEMBL304567 | — | — | 1 | - |
| CHEMBL305876 | — | — | 1 | - |
| CHEMBL72650 | — | — | 1 | - |
| CHEMBL305998 | — | — | 1 | - |
| CHEMBL306714 | — | — | 1 | - |
| CHEMBL72735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL70690 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL70336 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL72703 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL421679 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL72319 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL70265 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL304567 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL305876 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL72650 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL305998 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL306714 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL72735 | — | Ki | > | 10000.0 | nM | - |