Assay Detail
Binding
CHEMBL805331
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Binding affinity for serotonin transporter was determined in rat cortical membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.96 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339863 | — | — | 1 | 6.63 |
| CHEMBL125795 | — | — | 1 | 5.78 |
| CHEMBL338411 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339863 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL125795 | — | Ki | = | 1679.0 | nM | 5.78 |
| CHEMBL338411 | — | Ki | = | 3422.0 | nM | 5.47 |