Assay Detail
Binding
CHEMBL805332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for serotonin transporter was determined in vitro in rat brain using [3H]citalopram as radioligand.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.97 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084870 | — | — | 1 | 6.59 |
| CHEMBL3084609 | — | — | 1 | 6.52 |
| CHEMBL3084621 | — | — | 1 | 6.37 |
| CHEMBL545574 | — | — | 1 | 6.25 |
| CHEMBL3084623 | — | — | 1 | 6.23 |
| CHEMBL542275 | — | — | 1 | 6.23 |
| CHEMBL3084607 | — | — | 1 | 6.18 |
| CHEMBL539829 | — | — | 1 | 6.14 |
| CHEMBL3084608 | — | — | 1 | 6.13 |
| CHEMBL543231 | — | — | 1 | 5.92 |
| CHEMBL539821 | — | — | 1 | 5.88 |
| CHEMBL3084884 | — | — | 1 | 5.79 |
| CHEMBL542521 | — | — | 1 | 5.78 |
| CHEMBL559215 | — | — | 1 | 5.68 |
| CHEMBL545342 | — | — | 1 | 5.63 |
| CHEMBL544177 | — | — | 1 | 5.45 |
| CHEMBL541612 | — | — | 1 | 5.44 |
| CHEMBL310310 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084870 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL3084609 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL3084621 | — | Ki | = | 429.0 | nM | 6.37 |
| CHEMBL545574 | — | Ki | = | 568.0 | nM | 6.25 |
| CHEMBL3084623 | — | Ki | = | 585.0 | nM | 6.23 |
| CHEMBL542275 | — | Ki | = | 591.0 | nM | 6.23 |
| CHEMBL3084607 | — | Ki | = | 659.0 | nM | 6.18 |
| CHEMBL539829 | — | Ki | = | 727.0 | nM | 6.14 |
| CHEMBL3084608 | — | Ki | = | 737.0 | nM | 6.13 |
| CHEMBL543231 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL539821 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL3084884 | — | Ki | = | 1640.0 | nM | 5.79 |
| CHEMBL542521 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL559215 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL545342 | — | Ki | = | 2330.0 | nM | 5.63 |
| CHEMBL544177 | — | Ki | = | 3530.0 | nM | 5.45 |
| CHEMBL541612 | — | Ki | = | 3610.0 | nM | 5.44 |
| CHEMBL310310 | — | Ki | = | 5120.0 | nM | 5.29 |