Assay Detail
Binding
CHEMBL805338
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Binding affinity towards serotonin transporter 5-HTT was determined using [3H]paroxetine radioligand.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.40 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103523 | — | — | 1 | 8.09 |
| CHEMBL317905 | — | — | 1 | 7.42 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.35 |
| CHEMBL316528 | — | — | 1 | 7.28 |
| CHEMBL1790051 | — | — | 1 | 6.74 |
| CHEMBL321780 | — | — | 1 | 6.68 |
| CHEMBL103227 | — | — | 1 | 6.55 |
| CHEMBL298580 | — | — | 1 | 6.52 |
| CHEMBL103228 | — | — | 1 | 6.46 |
| CHEMBL322856 | — | — | 1 | 6.44 |
| CHEMBL316585 | — | — | 1 | 6.33 |
| CHEMBL322385 | — | — | 1 | 6.28 |
| CHEMBL320627 | — | — | 1 | 6.27 |
| CHEMBL317904 | — | — | 1 | 6.24 |
| CHEMBL329517 | — | — | 1 | 6.18 |
| CHEMBL321806 | — | — | 1 | 5.94 |
| CHEMBL14144 | — | — | 1 | 5.75 |
| CHEMBL100652 | — | — | 1 | 5.47 |
| CHEMBL322400 | — | — | 1 | 5.41 |
| CHEMBL317909 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103523 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL317905 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL370805 | COCAINE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL316528 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL1790051 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL321780 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL103227 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL298580 | — | Ki | = | 305.0 | nM | 6.52 |
| CHEMBL103228 | — | Ki | = | 348.0 | nM | 6.46 |
| CHEMBL322856 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL316585 | — | Ki | = | 465.0 | nM | 6.33 |
| CHEMBL322385 | — | Ki | = | 522.0 | nM | 6.28 |
| CHEMBL320627 | — | Ki | = | 535.0 | nM | 6.27 |
| CHEMBL317904 | — | Ki | = | 582.0 | nM | 6.24 |
| CHEMBL329517 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL321806 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL14144 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL100652 | — | Ki | = | 3350.0 | nM | 5.47 |
| CHEMBL322400 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL317909 | — | Ki | = | 26000.0 | nM | 4.58 |