Assay Detail
Binding
CHEMBL805339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards serotonin transporter using [3H]citalopram as radioligand was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.02 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42553 | — | — | 1 | 8.84 |
| CHEMBL310650 | — | — | 1 | 6.16 |
| CHEMBL98279 | — | — | 1 | 5.82 |
| CHEMBL317362 | — | — | 1 | 5.73 |
| CHEMBL316634 | — | — | 1 | 5.69 |
| CHEMBL95775 | — | — | 1 | 5.50 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 5.49 |
| CHEMBL99038 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42553 | — | Ki | = | 1.46 | nM | 8.84 |
| CHEMBL310650 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL98279 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL317362 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL316634 | — | Ki | = | 2040.0 | nM | 5.69 |
| CHEMBL95775 | — | Ki | = | 3160.0 | nM | 5.50 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL99038 | — | Ki | = | 12000.0 | nM | 4.92 |