Assay Detail
Binding
CHEMBL805340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards rat serotonin transporter (SERT)
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 51 | 6.48 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29003 | — | — | 1 | 8.52 |
| CHEMBL27748 | — | — | 1 | 8.52 |
| CHEMBL286949 | — | — | 1 | 8.52 |
| CHEMBL28660 | — | — | 1 | 7.52 |
| CHEMBL29040 | — | — | 1 | 7.50 |
| CHEMBL10914 | — | — | 1 | 7.30 |
| CHEMBL29286 | — | — | 1 | 7.28 |
| CHEMBL28414 | — | — | 1 | 7.24 |
| CHEMBL28712 | — | — | 1 | 7.23 |
| CHEMBL28907 | — | — | 1 | 7.16 |
| CHEMBL283620 | — | — | 1 | 7.03 |
| CHEMBL28505 | — | — | 1 | 7.00 |
| CHEMBL31361 | — | — | 1 | 6.96 |
| CHEMBL28867 | — | — | 1 | 6.96 |
| CHEMBL417660 | — | — | 1 | 6.92 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 6.90 |
| CHEMBL286991 | — | — | 1 | 6.87 |
| CHEMBL285566 | — | — | 1 | 6.82 |
| CHEMBL282312 | — | — | 1 | 6.66 |
| CHEMBL283662 | — | — | 1 | 6.66 |
| CHEMBL28897 | — | — | 1 | 6.58 |
| CHEMBL28236 | — | — | 1 | 6.47 |
| CHEMBL416752 | — | — | 1 | 6.46 |
| CHEMBL29065 | — | — | 1 | 6.36 |
| CHEMBL283646 | — | — | 1 | 6.32 |
| CHEMBL416198 | — | — | 1 | 6.32 |
| CHEMBL416022 | — | — | 1 | 6.30 |
| CHEMBL28876 | — | — | 1 | 6.28 |
| CHEMBL28935 | — | — | 1 | 6.28 |
| CHEMBL29151 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29003 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL286949 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL27748 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL28660 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL29040 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL10914 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL29286 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL28414 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL28712 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL28907 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL283620 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL28505 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL28867 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL31361 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL417660 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL281594 | VANOXERINE | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL286991 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL285566 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL282312 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL283662 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL28897 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL28236 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL416752 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL29065 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL416198 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL283646 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL416022 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL28876 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL28935 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL29151 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL26320 | — | Ki | = | 623.0 | nM | 6.21 |
| CHEMBL28821 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL28598 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL28133 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL421862 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL29000 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL281669 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL28726 | — | Ki | = | 1130.0 | nM | 5.95 |
| CHEMBL283837 | — | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL27907 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL27626 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL28947 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL31571 | — | Ki | = | 1940.0 | nM | 5.71 |
| CHEMBL28191 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL28306 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL30257 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL430537 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL28125 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL417305 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL282821 | — | Ki | = | 4100.0 | nM | 5.39 |