Assay Detail
Binding
CHEMBL805342
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Binding affinity to serotonin transporter (SERT) in rat forebrain tissue
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Forebrain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.34 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14613 | — | — | 1 | 10.21 |
| CHEMBL311347 | — | — | 1 | 9.39 |
| CHEMBL66068 | — | — | 1 | 8.87 |
| CHEMBL67387 | — | — | 1 | 8.01 |
| CHEMBL294733 | — | — | 1 | 7.45 |
| CHEMBL303494 | — | — | 1 | 7.38 |
| CHEMBL303232 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14613 | — | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL311347 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL66068 | — | Ki | = | 1.35 | nM | 8.87 |
| CHEMBL67387 | — | Ki | = | 9.82 | nM | 8.01 |
| CHEMBL294733 | — | Ki | = | 35.2 | nM | 7.45 |
| CHEMBL303494 | — | Ki | = | 41.7 | nM | 7.38 |
| CHEMBL303232 | — | Ki | = | 82.5 | nM | 7.08 |