Assay Detail
Binding
CHEMBL805515
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to serotonin transporter (SERT) in membranes of cells selectively expressing the human genes for SERT
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.75 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66068 | — | — | 1 | 8.91 |
| CHEMBL67387 | — | — | 1 | 8.02 |
| CHEMBL294733 | — | — | 1 | 7.41 |
| CHEMBL303494 | — | — | 1 | 7.26 |
| CHEMBL303232 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66068 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL67387 | — | Ki | = | 9.63 | nM | 8.02 |
| CHEMBL294733 | — | Ki | = | 38.6 | nM | 7.41 |
| CHEMBL303494 | — | Ki | = | 55.1 | nM | 7.26 |
| CHEMBL303232 | — | Ki | = | 74.1 | nM | 7.13 |