Assay Detail
Binding
CHEMBL805614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.78 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20768 | — | — | 1 | 8.17 |
| CHEMBL293952 | — | — | 1 | 8.08 |
| CHEMBL53170 | — | — | 1 | 8.02 |
| CHEMBL20807 | — | — | 1 | 7.98 |
| CHEMBL54808 | — | — | 1 | 7.57 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.54 |
| CHEMBL276500 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20768 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL293952 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL53170 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL20807 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL54808 | — | Ki | = | 27.1 | nM | 7.57 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 28.8 | nM | 7.54 |
| CHEMBL276500 | — | Ki | = | 78.5 | nM | 7.11 |