Assay Detail
Binding
CHEMBL805615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.64 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325238 | — | — | 1 | 9.10 |
| CHEMBL112124 | — | — | 1 | 8.96 |
| CHEMBL115508 | — | — | 1 | 8.52 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325238 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL112124 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL115508 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 10.4 | nM | 7.98 |