Assay Detail
Binding
CHEMBL805626
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In vitro binding affinity against Serotonin transporter (SERT) from LLC-PK1 cell membranes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Cell Type | LLC-PK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 10.10 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361259 | — | — | 1 | 11.00 |
| CHEMBL114275 | — | — | 1 | 10.01 |
| CHEMBL278165 | — | — | 1 | 9.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361259 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL114275 | — | Ki | = | 0.097 | nM | 10.01 |
| CHEMBL278165 | — | Ki | = | 0.52 | nM | 9.28 |