Assay Detail
Binding
CHEMBL805629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
50% Inhibition against Serotonin transporter in rat midbrain tissue by displacing [3H]paroxetine radioligand
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Midbrain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.82 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2310867 | — | — | 1 | 9.10 |
| CHEMBL3350431 | — | — | 1 | 8.36 |
| CHEMBL2310868 | — | — | 1 | 8.02 |
| CHEMBL2310874 | — | — | 1 | 7.94 |
| CHEMBL2310884 | — | — | 1 | 7.94 |
| CHEMBL2310871 | — | — | 1 | 7.88 |
| CHEMBL2310869 | — | — | 1 | 7.80 |
| CHEMBL50157 | — | — | 1 | 7.55 |
| CHEMBL2310872 | — | — | 1 | 7.33 |
| CHEMBL2310866 | — | — | 1 | 7.15 |
| CHEMBL2310876 | — | — | 1 | 7.02 |
| CHEMBL2310877 | — | — | 1 | 6.63 |
| CHEMBL2373962 | — | — | 1 | 6.62 |
| CHEMBL2310883 | — | — | 1 | 6.47 |
| CHEMBL84680 | — | — | 1 | 6.46 |
| CHEMBL2310881 | — | — | 1 | 6.11 |
| CHEMBL2310870 | — | — | 1 | 6.08 |
| CHEMBL2310878 | — | — | 1 | 5.91 |
| CHEMBL2310875 | — | — | 1 | 5.87 |
| CHEMBL1790051 | — | — | 1 | 5.71 |
| CHEMBL2310873 | — | — | 1 | 5.66 |
| CHEMBL2310879 | — | — | 1 | 5.57 |
| CHEMBL2310865 | — | — | 1 | 5.32 |
| CHEMBL2310880 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2310867 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3350431 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2310868 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL2310874 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL2310884 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL2310871 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL2310869 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL50157 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL2310872 | — | IC50 | = | 46.8 | nM | 7.33 |
| CHEMBL2310866 | — | IC50 | = | 70.4 | nM | 7.15 |
| CHEMBL2310876 | — | IC50 | = | 95.8 | nM | 7.02 |
| CHEMBL2310877 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL2373962 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2310883 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL84680 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL2310881 | — | IC50 | = | 781.0 | nM | 6.11 |
| CHEMBL2310870 | — | IC50 | = | 828.0 | nM | 6.08 |
| CHEMBL2310878 | — | IC50 | = | 1243.0 | nM | 5.91 |
| CHEMBL2310875 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL1790051 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL2310873 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL2310879 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL2310865 | — | IC50 | = | 4824.0 | nM | 5.32 |
| CHEMBL2310880 | — | IC50 | = | 7240.0 | nM | 5.14 |