Assay Detail
Binding
CHEMBL805631
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Ability to inhibit Serotonin transporter
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Bivalent indoles exhibiting serotonergic binding affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.61 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22961 | — | — | 1 | 7.91 |
| CHEMBL22553 | — | — | 1 | 7.90 |
| CHEMBL22744 | — | — | 1 | 7.75 |
| CHEMBL21862 | — | — | 1 | 7.47 |
| CHEMBL17828 | — | — | 1 | 7.32 |
| CHEMBL277452 | — | — | 1 | 7.32 |
| CHEMBL278610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22961 | — | IC50 | = | 12.42 | nM | 7.91 |
| CHEMBL22553 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL22744 | — | IC50 | = | 17.67 | nM | 7.75 |
| CHEMBL21862 | — | IC50 | = | 33.91 | nM | 7.47 |
| CHEMBL17828 | — | IC50 | = | 47.54 | nM | 7.32 |
| CHEMBL277452 | — | IC50 | = | 47.76 | nM | 7.32 |
| CHEMBL278610 | — | IC50 | - | nM | - |