Assay Detail
Binding
CHEMBL805715
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In vitro binding affinity at somatostatin 2 receptor in transfected HEK 293 cell using [125 I]Tyr11-SRIF-14 as radioligand
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.13 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | 3.0 | 1 | 9.70 |
| CHEMBL3350037 | — | — | 1 | 9.52 |
| CHEMBL311695 | SEGLITIDE | 2.0 | 1 | 9.52 |
| CHEMBL140151 | — | — | 1 | 6.51 |
| CHEMBL344404 | — | — | 1 | 6.30 |
| CHEMBL433872 | — | — | 1 | 6.25 |
| CHEMBL103769 | — | — | 1 | 6.21 |
| CHEMBL142986 | — | — | 1 | 6.11 |
| CHEMBL359215 | — | — | 1 | 6.11 |
| CHEMBL145472 | — | — | 1 | 6.08 |
| CHEMBL142422 | — | — | 1 | 6.05 |
| CHEMBL143668 | — | — | 1 | 6.00 |
| CHEMBL142402 | — | — | 1 | 6.00 |
| CHEMBL142283 | — | — | 1 | 5.80 |
| CHEMBL142549 | — | — | 1 | 5.77 |
| CHEMBL142613 | — | — | 1 | 5.77 |
| CHEMBL344285 | — | — | 1 | 5.70 |
| CHEMBL143409 | — | — | 1 | 5.70 |
| CHEMBL143164 | — | — | 1 | 5.70 |
| CHEMBL142823 | — | — | 1 | 5.66 |
| CHEMBL142321 | — | — | 1 | 5.64 |
| CHEMBL359453 | — | — | 1 | 5.60 |
| CHEMBL344074 | — | — | 1 | 5.52 |
| CHEMBL344059 | — | — | 1 | 5.38 |
| CHEMBL143100 | — | — | 1 | 5.34 |
| CHEMBL142492 | — | — | 1 | 5.10 |
| CHEMBL142822 | — | — | 1 | 4.48 |
| CHEMBL142295 | — | — | 1 | 4.13 |
| CHEMBL142811 | — | — | 1 | - |
| CHEMBL422475 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3350037 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL311695 | SEGLITIDE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL140151 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL344404 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL433872 | — | Ki | = | 565.0 | nM | 6.25 |
| CHEMBL103769 | — | Ki | = | 621.0 | nM | 6.21 |
| CHEMBL142986 | — | Ki | = | 778.0 | nM | 6.11 |
| CHEMBL359215 | — | Ki | = | 777.0 | nM | 6.11 |
| CHEMBL145472 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL142422 | — | Ki | = | 894.0 | nM | 6.05 |
| CHEMBL143668 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL142402 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL142283 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL142613 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL142549 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL143164 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL143409 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL344285 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL142823 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL142321 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL359453 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL344074 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL344059 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL143100 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL142492 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL142822 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL142295 | — | Ki | = | 74000.0 | nM | 4.13 |
| CHEMBL142811 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL422475 | — | Ki | = | 114000.0 | nM | - |
| CHEMBL342781 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL143245 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL143539 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL142293 | — | Ki | > | 300000.0 | nM | - |