Assay Detail
Binding
CHEMBL806134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]- paroxetine from Serotonin transporter in rat cerebral cortical homogenate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.00 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14613 | — | — | 1 | 10.22 |
| CHEMBL311347 | — | — | 1 | 9.34 |
| CHEMBL318755 | — | — | 1 | 8.78 |
| CHEMBL318961 | — | — | 1 | 8.78 |
| CHEMBL105693 | — | — | 1 | 8.78 |
| CHEMBL317444 | — | — | 1 | 7.88 |
| CHEMBL433159 | — | — | 1 | 7.44 |
| CHEMBL430504 | — | — | 1 | 6.49 |
| CHEMBL105089 | — | — | 1 | 6.43 |
| CHEMBL319052 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14613 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL311347 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL318755 | — | Ki | = | 1.68 | nM | 8.78 |
| CHEMBL318961 | — | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL105693 | — | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL317444 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL433159 | — | Ki | = | 36.4 | nM | 7.44 |
| CHEMBL430504 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL105089 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL319052 | — | Ki | = | 1311.0 | nM | 5.88 |