Assay Detail
Binding
CHEMBL806136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]paroxetine bound to Serotonin transporter receptor in rat forebrain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.72 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41140 | 6-NITROQUIPAZINE | — | 1 | 9.92 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 7.51 |
| CHEMBL352107 | — | — | 1 | 7.23 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.13 |
| CHEMBL43355 | — | — | 1 | 4.92 |
| CHEMBL287987 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41140 | 6-NITROQUIPAZINE | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL352107 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL39 | SEROTONIN | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL43355 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL287987 | — | Ki | = | 24000.0 | nM | 4.62 |