Assay Detail
Binding
CHEMBL806537
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Inhibition of [3H]paroxetine binding to Serotonin transporter
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.88 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311347 | — | — | 1 | 8.38 |
| CHEMBL610897 | — | — | 1 | 7.35 |
| CHEMBL312037 | — | — | 1 | 6.62 |
| CHEMBL82946 | — | — | 1 | 6.51 |
| CHEMBL313038 | — | — | 1 | 6.49 |
| CHEMBL84244 | — | — | 1 | 6.43 |
| CHEMBL2079586 | — | — | 1 | 6.12 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.97 |
| CHEMBL82093 | — | — | 1 | 5.85 |
| CHEMBL83729 | — | — | 1 | 5.70 |
| CHEMBL310573 | — | — | 1 | 5.63 |
| CHEMBL311177 | — | — | 1 | 5.38 |
| CHEMBL309635 | — | — | 1 | 5.19 |
| CHEMBL310131 | — | — | 1 | 5.04 |
| CHEMBL314465 | — | — | 1 | 4.59 |
| CHEMBL86165 | — | — | 1 | 4.53 |
| CHEMBL314464 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311347 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL610897 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL312037 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL82946 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL313038 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL84244 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL2079586 | — | IC50 | = | 759.0 | nM | 6.12 |
| CHEMBL370805 | COCAINE | IC50 | = | 1059.0 | nM | 5.97 |
| CHEMBL82093 | — | IC50 | = | 1404.0 | nM | 5.85 |
| CHEMBL83729 | — | IC50 | = | 1999.0 | nM | 5.70 |
| CHEMBL310573 | — | IC50 | = | 2335.0 | nM | 5.63 |
| CHEMBL311177 | — | IC50 | = | 4129.0 | nM | 5.38 |
| CHEMBL309635 | — | IC50 | = | 6406.0 | nM | 5.19 |
| CHEMBL310131 | — | IC50 | = | 9057.0 | nM | 5.04 |
| CHEMBL314465 | — | IC50 | = | 25733.0 | nM | 4.59 |
| CHEMBL86165 | — | IC50 | = | 29666.0 | nM | 4.53 |
| CHEMBL314464 | — | IC50 | = | 57368.0 | nM | 4.24 |