Assay Detail
Binding
CHEMBL806543
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Binding affinity at serotonin transporter in rat striatum by [3H]citalopram displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.90 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 6.88 |
| CHEMBL39262 | — | — | 1 | 6.86 |
| CHEMBL2114063 | — | — | 1 | 6.36 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.13 |
| CHEMBL2112226 | — | — | 1 | 6.06 |
| CHEMBL2112227 | — | — | 1 | 5.98 |
| CHEMBL2111541 | — | — | 1 | 5.95 |
| CHEMBL3216629 | — | — | 1 | 5.88 |
| CHEMBL2112224 | — | — | 1 | 5.81 |
| CHEMBL2112229 | — | — | 1 | 5.75 |
| CHEMBL2448150 | — | — | 1 | 5.67 |
| CHEMBL3216400 | — | — | 1 | 5.66 |
| CHEMBL40607 | — | — | 1 | 5.65 |
| CHEMBL2112228 | — | — | 1 | 5.65 |
| CHEMBL2448151 | — | — | 1 | 5.56 |
| CHEMBL2112225 | — | — | 1 | 5.52 |
| CHEMBL3215982 | — | — | 1 | 5.45 |
| CHEMBL2448152 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL39262 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL2114063 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL370805 | COCAINE | IC50 | = | 737.0 | nM | 6.13 |
| CHEMBL2112226 | — | IC50 | = | 862.0 | nM | 6.06 |
| CHEMBL2112227 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL2111541 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL3216629 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL2112224 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL2112229 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2448150 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL3216400 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL40607 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL2112228 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL2448151 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL2112225 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL3215982 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL2448152 | — | IC50 | = | 3650.0 | nM | 5.44 |