Assay Detail
Binding
CHEMBL806548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
IC50 value was evaluated using [3H]citalopram (radioligand) on serotonin transporter in rat striatum.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.43 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.06 |
| CHEMBL34032 | — | — | 1 | 6.70 |
| CHEMBL110530 | — | — | 1 | 6.23 |
| CHEMBL20648 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL34032 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL110530 | — | IC50 | = | 585.0 | nM | 6.23 |
| CHEMBL20648 | — | IC50 | = | 1920.0 | nM | 5.72 |