Assay Detail
Binding
CHEMBL806553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required to inhibit serotonin transporter 5-HTT was determined by using [3H]paroxetine radioligand
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.56 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103523 | — | — | 1 | 7.04 |
| CHEMBL317905 | — | — | 1 | 6.38 |
| CHEMBL298580 | — | — | 1 | 6.30 |
| CHEMBL316528 | — | — | 1 | 6.24 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.98 |
| CHEMBL321806 | — | — | 1 | 5.71 |
| CHEMBL1790051 | — | — | 1 | 5.70 |
| CHEMBL321780 | — | — | 1 | 5.63 |
| CHEMBL14144 | — | — | 1 | 5.53 |
| CHEMBL103227 | — | — | 1 | 5.51 |
| CHEMBL103228 | — | — | 1 | 5.42 |
| CHEMBL322856 | — | — | 1 | 5.39 |
| CHEMBL316585 | — | — | 1 | 5.29 |
| CHEMBL322385 | — | — | 1 | 5.24 |
| CHEMBL320627 | — | — | 1 | 5.23 |
| CHEMBL317904 | — | — | 1 | 5.19 |
| CHEMBL329517 | — | — | 1 | 5.14 |
| CHEMBL100652 | — | — | 1 | 4.43 |
| CHEMBL322400 | — | — | 1 | 4.37 |
| CHEMBL103867 | — | — | 1 | - |
| CHEMBL103223 | — | — | 1 | - |
| CHEMBL328415 | — | — | 1 | - |
| CHEMBL317909 | — | — | 1 | - |
| CHEMBL102279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103523 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL317905 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL298580 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL316528 | — | IC50 | = | 572.0 | nM | 6.24 |
| CHEMBL370805 | COCAINE | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL321806 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL1790051 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL321780 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL14144 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL103227 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL103228 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL322856 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL316585 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL322385 | — | IC50 | = | 5741.0 | nM | 5.24 |
| CHEMBL320627 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL317904 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL329517 | — | IC50 | = | 7260.0 | nM | 5.14 |
| CHEMBL100652 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL322400 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL103867 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL103223 | — | IC50 | > | 76000.0 | nM | - |
| CHEMBL328415 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL317909 | — | IC50 | = | 295000.0 | nM | - |
| CHEMBL102279 | — | IC50 | > | 100000.0 | nM | - |