Assay Detail
Binding
CHEMBL806554
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Inhibition of [3H]paroxetine binding at serotonin transporter was determined
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.86 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51154 | — | — | 1 | 9.22 |
| CHEMBL297507 | — | — | 1 | 9.16 |
| CHEMBL2373961 | — | — | 1 | 8.50 |
| CHEMBL300226 | — | — | 1 | 8.38 |
| CHEMBL2310926 | — | — | 1 | 8.15 |
| CHEMBL301562 | — | — | 1 | 8.09 |
| CHEMBL50858 | — | — | 1 | 7.98 |
| CHEMBL2310929 | — | — | 1 | 7.97 |
| CHEMBL50157 | — | — | 1 | 7.55 |
| CHEMBL300220 | — | — | 1 | 7.41 |
| CHEMBL610897 | — | — | 1 | 7.35 |
| CHEMBL301938 | — | — | 1 | 7.01 |
| CHEMBL2373962 | — | — | 1 | 6.62 |
| CHEMBL51617 | — | — | 1 | 6.30 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.98 |
| CHEMBL52324 | — | — | 1 | 5.97 |
| CHEMBL1643896 | — | — | 1 | 5.76 |
| CHEMBL1790051 | — | — | 1 | 5.71 |
| CHEMBL14144 | — | — | 1 | 5.63 |
| CHEMBL298580 | — | — | 1 | 5.62 |
| CHEMBL432878 | — | — | 1 | 5.24 |
| CHEMBL298703 | — | — | 1 | 5.21 |
| CHEMBL51771 | — | — | 1 | 4.96 |
| CHEMBL51355 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51154 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL297507 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL2373961 | — | IC50 | = | 3.13 | nM | 8.50 |
| CHEMBL300226 | — | IC50 | = | 4.21 | nM | 8.38 |
| CHEMBL2310926 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL301562 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL50858 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL2310929 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL50157 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL300220 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL610897 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL301938 | — | IC50 | = | 97.4 | nM | 7.01 |
| CHEMBL2373962 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL51617 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL370805 | COCAINE | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL52324 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL1643896 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL1790051 | — | IC50 | = | 1962.0 | nM | 5.71 |
| CHEMBL14144 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL298580 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL432878 | — | IC50 | = | 5740.0 | nM | 5.24 |
| CHEMBL298703 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL51771 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL51355 | — | IC50 | = | 12400.0 | nM | 4.91 |