Assay Detail
Binding
CHEMBL806555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.97 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334877 | — | — | 1 | 9.22 |
| CHEMBL132499 | — | — | 1 | 8.94 |
| CHEMBL340447 | — | — | 1 | 8.89 |
| CHEMBL442763 | — | — | 1 | 8.80 |
| CHEMBL132513 | — | — | 1 | 8.65 |
| CHEMBL128186 | — | — | 1 | 8.50 |
| CHEMBL336190 | — | — | 1 | 8.50 |
| CHEMBL131662 | — | — | 1 | 8.36 |
| CHEMBL337507 | — | — | 1 | 8.21 |
| CHEMBL335001 | — | — | 1 | 8.15 |
| CHEMBL340523 | — | — | 1 | 8.09 |
| CHEMBL129608 | — | — | 1 | 8.02 |
| CHEMBL132329 | — | — | 1 | 7.94 |
| CHEMBL335868 | — | — | 1 | 7.82 |
| CHEMBL127557 | — | — | 1 | 7.80 |
| CHEMBL131354 | — | — | 1 | 7.58 |
| CHEMBL130750 | — | — | 1 | 7.55 |
| CHEMBL334546 | — | — | 1 | 7.55 |
| CHEMBL129662 | — | — | 1 | 7.15 |
| CHEMBL301281 | — | — | 1 | 6.90 |
| CHEMBL337980 | — | — | 1 | 6.72 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334877 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL132499 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL340447 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL442763 | — | IC50 | = | 1.59 | nM | 8.80 |
| CHEMBL132513 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL128186 | — | IC50 | = | 3.13 | nM | 8.50 |
| CHEMBL336190 | — | IC50 | = | 3.16 | nM | 8.50 |
| CHEMBL131662 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL337507 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL335001 | — | IC50 | = | 7.09 | nM | 8.15 |
| CHEMBL340523 | — | IC50 | = | 8.13 | nM | 8.09 |
| CHEMBL129608 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL132329 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL335868 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL127557 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL131354 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL130750 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL334546 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL129662 | — | IC50 | = | 70.4 | nM | 7.15 |
| CHEMBL301281 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL337980 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL370805 | COCAINE | IC50 | = | 1045.0 | nM | 5.98 |