Assay Detail
Binding
CHEMBL806802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for the displacement of [3H]paroxetine binding to serotonin transporter (SERT) in rat frontal cortex membranes
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.15 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36720 | — | — | 1 | 9.64 |
| CHEMBL287945 | — | — | 1 | 9.43 |
| CHEMBL34243 | — | — | 1 | 9.42 |
| CHEMBL418190 | — | — | 2 | 9.41 |
| CHEMBL435371 | — | — | 1 | 9.33 |
| CHEMBL22930 | — | — | 1 | 8.97 |
| CHEMBL416058 | — | — | 1 | 8.71 |
| CHEMBL39589 | — | — | 1 | 8.68 |
| CHEMBL39990 | — | — | 1 | 8.65 |
| CHEMBL290412 | — | — | 1 | 8.64 |
| CHEMBL287940 | — | — | 1 | 8.12 |
| CHEMBL39340 | — | — | 1 | 8.05 |
| CHEMBL39330 | — | — | 1 | 7.82 |
| CHEMBL289849 | — | — | 1 | 7.80 |
| CHEMBL278572 | — | — | 1 | 7.68 |
| CHEMBL23672 | — | — | 2 | 7.58 |
| CHEMBL278122 | — | — | 1 | 7.44 |
| CHEMBL39764 | — | — | 1 | 7.06 |
| CHEMBL23142 | — | — | 1 | 6.88 |
| CHEMBL290662 | — | — | 1 | 6.87 |
| CHEMBL285039 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36720 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL287945 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL34243 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL418190 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL435371 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL22930 | — | Ki | = | 1.06 | nM | 8.97 |
| CHEMBL416058 | — | Ki | = | 1.97 | nM | 8.71 |
| CHEMBL39589 | — | Ki | = | 2.08 | nM | 8.68 |
| CHEMBL39990 | — | Ki | = | 2.24 | nM | 8.65 |
| CHEMBL290412 | — | Ki | = | 2.27 | nM | 8.64 |
| CHEMBL287940 | — | Ki | = | 7.55 | nM | 8.12 |
| CHEMBL39340 | — | Ki | = | 8.99 | nM | 8.05 |
| CHEMBL39330 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL289849 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL418190 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL278572 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL23672 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL278122 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL39764 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL23142 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL290662 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL285039 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL23672 | — | Ki | = | 217.0 | nM | 6.66 |