Assay Detail
Binding
CHEMBL806803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for RB Serotonin transporter was determined in vitro by incubating compound
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.28 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106481 | — | — | 1 | 11.00 |
| CHEMBL421027 | — | — | 1 | 10.52 |
| CHEMBL105204 | — | — | 1 | 9.82 |
| CHEMBL104144 | — | — | 1 | 9.77 |
| CHEMBL318604 | — | — | 1 | 9.64 |
| CHEMBL105390 | — | — | 1 | 8.93 |
| CHEMBL104229 | — | — | 1 | 8.84 |
| CHEMBL322915 | — | — | 1 | 8.33 |
| CHEMBL442391 | — | — | 1 | 8.16 |
| CHEMBL318738 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106481 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL421027 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL105204 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL104144 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL318604 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL105390 | — | Ki | = | 1.17 | nM | 8.93 |
| CHEMBL104229 | — | Ki | = | 1.46 | nM | 8.84 |
| CHEMBL322915 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL442391 | — | Ki | = | 6.89 | nM | 8.16 |
| CHEMBL318738 | — | Ki | = | 18.0 | nM | 7.75 |