Assay Detail
Binding
CHEMBL806861
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Inhibition of [3H]citalopram binding to serotonin transporter (SERT) of cynomolgus monkey caudate-putamen
14
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | monkey |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.13 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169471 | — | — | 1 | 8.91 |
| CHEMBL87031 | — | — | 2 | 8.60 |
| CHEMBL316342 | — | — | 4 | 8.33 |
| CHEMBL100941 | — | — | 2 | 7.48 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.57 |
| CHEMBL88915 | — | — | 1 | 6.06 |
| CHEMBL169429 | — | — | 2 | 5.71 |
| CHEMBL322923 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169471 | — | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL87031 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL316342 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL316342 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL87031 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL316342 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL100941 | — | IC50 | = | 33.4 | nM | 7.48 |
| CHEMBL316342 | — | IC50 | = | 64.5 | nM | 7.19 |
| CHEMBL100941 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL370805 | COCAINE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL88915 | — | IC50 | = | 867.0 | nM | 6.06 |
| CHEMBL169429 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL169429 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL322923 | — | IC50 | = | 5160.0 | nM | 5.29 |