Assay Detail
Binding
CHEMBL806971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at serotonin transporter from rat brain striatal membrane by [3H]citalopram displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.61 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352272 | — | — | 1 | 7.50 |
| CHEMBL77867 | — | — | 1 | 7.26 |
| CHEMBL9329 | — | — | 1 | 7.24 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.09 |
| CHEMBL351215 | — | — | 1 | 6.99 |
| CHEMBL350100 | — | — | 1 | 6.95 |
| CHEMBL34032 | — | — | 1 | 6.70 |
| CHEMBL353797 | — | — | 1 | 6.65 |
| CHEMBL351595 | — | — | 1 | 6.63 |
| CHEMBL349281 | — | — | 1 | 6.62 |
| CHEMBL166072 | — | — | 1 | 6.47 |
| CHEMBL422018 | — | — | 1 | 6.38 |
| CHEMBL166122 | — | — | 1 | 6.34 |
| CHEMBL415747 | — | — | 1 | 6.26 |
| CHEMBL165657 | — | — | 1 | 6.20 |
| CHEMBL338733 | — | — | 1 | 6.13 |
| CHEMBL162006 | — | — | 1 | 6.12 |
| CHEMBL350372 | — | — | 1 | 6.08 |
| CHEMBL165740 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352272 | — | IC50 | = | 31.9 | nM | 7.50 |
| CHEMBL77867 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL9329 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL281594 | VANOXERINE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL351215 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL350100 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL34032 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL353797 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL351595 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL349281 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL166072 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL422018 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL166122 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL415747 | — | IC50 | = | 544.0 | nM | 6.26 |
| CHEMBL165657 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL338733 | — | IC50 | = | 743.0 | nM | 6.13 |
| CHEMBL162006 | — | IC50 | = | 761.0 | nM | 6.12 |
| CHEMBL350372 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL165740 | — | IC50 | = | 888.0 | nM | 6.05 |