Assay Detail
Binding
CHEMBL806972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity was evaluated by measuring inhibiting the binding of [3H]citalopram to Serotonin transporter in rat brain tissue
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.93 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39262 | — | — | 1 | 6.86 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.13 |
| CHEMBL40607 | — | — | 2 | 5.88 |
| CHEMBL78048 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39262 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL370805 | COCAINE | IC50 | = | 737.0 | nM | 6.13 |
| CHEMBL40607 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL40607 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL78048 | — | IC50 | = | 6210.0 | nM | 5.21 |