Assay Detail
Binding
CHEMBL806973
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Binding affinity towards Serotonin transporter was determined using 5-HT [3H]paroxetine as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.90 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411433 | — | — | 1 | 6.71 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.98 |
| CHEMBL117735 | — | — | 1 | 5.95 |
| CHEMBL14144 | — | — | 1 | 5.63 |
| CHEMBL298580 | — | — | 1 | 5.62 |
| CHEMBL116195 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411433 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL370805 | COCAINE | IC50 | = | 1045.0 | nM | 5.98 |
| CHEMBL117735 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL14144 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL298580 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL116195 | — | IC50 | = | 3300.0 | nM | 5.48 |