Assay Detail
Binding
CHEMBL807055
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Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cells expressing cloned human SRIF receptor (sst-4) subtype
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.90 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | 3.0 | 1 | 9.20 |
| CHEMBL103769 | — | — | 1 | 8.22 |
| CHEMBL2069499 | — | — | 1 | 5.15 |
| CHEMBL1237140 | — | — | 1 | 5.01 |
| CHEMBL1201959 | — | — | 1 | - |
| CHEMBL2367844 | — | — | 1 | - |
| CHEMBL2367837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL103769 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2069499 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL1237140 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL1201959 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2367844 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2367837 | — | Ki | > | 10000.0 | nM | - |