Compound Detail
CHEMBL2367844
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Basic Information
| ChEMBL ID | CHEMBL2367844 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VOSXUKXXGOUBDV-DCCUJTHKSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
410.6
MW (Da)
6.24
ALogP
2
HBA
3
HBD
56.5
PSA (Ų)
0.37
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.05
IC50 1 meas. best 8.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 3 CHEMBL2028 | Ki | 9.05 | 9.05 | 0.9 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | IC50 | 8.27 | 8.27 | 5.4 | 1 |
| Somatostatin receptor type 1 CHEMBL1917 | Ki | 5.36 | 5.36 | 4400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 3 | Ki | = | 0.9 | nM | 9.05 | Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cell... | 11520208 |
| Somatostatin receptor type 3 | IC50 | = | 5.4 | nM | 8.27 | Inhibitory concentration required to inhibit SRIF-14 induced reduction of cAMP i... | 11520208 |
| Somatostatin receptor type 1 | Ki | = | 4400.0 | nM | 5.36 | Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cell... | 11520208 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 3 | 2 |
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 1 | 1 |
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 2 | 1 |
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 4 | 1 |
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine