Assay Detail
Functional
CHEMBL807106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required to inhibit SRIF-14 induced reduction of cAMP in CHO-K1 cells expressing the human sst3 receptor.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.93 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2367837 | — | — | 1 | 9.08 |
| CHEMBL2069499 | — | — | 1 | 8.57 |
| CHEMBL2367844 | — | — | 1 | 8.27 |
| CHEMBL1237140 | — | — | 1 | 8.17 |
| CHEMBL1201959 | — | — | 1 | 7.72 |
| CHEMBL321282 | — | — | 1 | 7.37 |
| CHEMBL173778 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2367837 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL2069499 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL2367844 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1237140 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1201959 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL321282 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL173778 | — | IC50 | = | 450.0 | nM | 6.35 |