Compound Detail
CHEMBL1237140
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Basic Information
| ChEMBL ID | CHEMBL1237140 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FOBFICSYUINKAA-DEOSSOPVSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
426.6
MW (Da)
7.02
ALogP
2
HBA
3
HBD
56.5
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 9.19
IC50 2 meas. best 8.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 3 CHEMBL2028 | Ki | 9.19 | 8.83 | 0.6 | 2 |
| Somatostatin receptor type 3 CHEMBL2028 | IC50 | 8.57 | 8.37 | 2.7 | 2 |
| Somatostatin receptor type 5 CHEMBL1792 | Ki | 5.43 | 5.43 | 3700.0 | 1 |
| Somatostatin receptor type 4 CHEMBL1853 | Ki | 5.01 | 5.01 | 9800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 3 | Ki | = | 0.64 | nM | 9.19 | Displacement of [125I]SS14 from human SST3 expressed in CHO membrane after 60 to... | 24944745 |
| Somatostatin receptor type 3 | IC50 | = | 2.7 | nM | 8.57 | Antagonist activity at human SST3 expressed in CHO-K1 cells assessed as inhibiti... | 24944745 |
| Somatostatin receptor type 3 | Ki | = | 3.4 | nM | 8.47 | Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cell... | 11520208 |
| Somatostatin receptor type 3 | IC50 | = | 6.8 | nM | 8.17 | Inhibitory concentration required to inhibit SRIF-14 induced reduction of cAMP i... | 11520208 |
| Somatostatin receptor type 5 | Ki | = | 3700.0 | nM | 5.43 | Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cell... | 11520208 |
| Somatostatin receptor type 4 | Ki | = | 9800.0 | nM | 5.01 | Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cell... | 11520208 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 3 | 2 |
| 24944745 | 10.1021/ml500079u | Somatostatin receptor type 3 | 2 |
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 1 | 1 |
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 2 | 1 |
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 4 | 1 |
| 11520208 | 10.1021/jm0108449 | Somatostatin receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine